| Variant | Engine | Drivetrain | Transmission | City | Highway | Combined | EV Range | Est. Annual Fuel Cost |
| CLS450 Hybrid | 3L 6-Cyl | Rear-Wheel Drive | Automatic 9-spd | 23 MPG | 30 MPG | 26 MPG | — | $2,900 / yr |
| CLS450 4matic Hybrid | 3L 6-Cyl | 4-Wheel Drive | Automatic 9-spd | 22 MPG | 29 MPG | 25 MPG | — | $3,050 / yr |
| AMG CLS53 4matic Plus Hybrid | 3L 6-Cyl | 4-Wheel Drive | Automatic 9-spd | 21 MPG | 26 MPG | 23 MPG | — | $3,300 / yr |
Data Boundary Note: EPA specifications are shown by certified vehicle configuration. NHTSA complaints and recall totals are recorded at the model-year level across all configurations.
| Tested Drivetrain / Cab Variant | Overall Rating | Frontal Crash | Side Crash | Rollover Rating | Rollover Risk |
| -Class 4 DR 4WD | Not Rated | Not Rated | Not Rated | Not Rated | — |
| -Class 4 DR RWD | Not Rated | Not Rated | Not Rated | Not Rated | — |
Active Driver Assistance Systems (NHTSA Recorded): Forward Collision Warning (FCW) is documented as Standard and Lane Departure Warning (LDW) is documented as No in official NHTSA records for tested 2021 Mercedes-Benz CLS models.
View complete 2021 Mercedes-Benz CLS crash test & safety breakdown →
Top Reported Problem Categories
Ranked by total consumer complaint submissions recorded by NHTSA
Data Attribution & Context: Complaints are self-reported by vehicle owners to NHTSA and represent unverified consumer submissions. Complaint volume does not equal a statistically controlled failure rate and is not adjusted for total vehicles sold or cumulative mileage driven.
View all 2021 Mercedes-Benz CLS problems & component breakdown (1 categories) →
Affected Component: ELECTRICAL SYSTEM:WIRING
Defect Summary: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.
Free Manufacturer Remedy: Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2024MMNNNN.
Affected Component: ELECTRICAL SYSTEM:12V/24V/48V BATTERY
Defect Summary: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2022 CLS450 Coupe and AMG E53, 2019-2021 AMG CLS53 Coupe, and 2021-2022 E450 vehicles. The 12-Volt battery in the trunk may not be properly secured, which, in the event of a crash, can cause electrical connection failure, disabling various safety features including, emergency call (eCall) system, electric seat adjustment, hazard warning lights, and automatic door locks.
Free Manufacturer Remedy: Dealers will secure the 12V battery, free of charge. Owner notification letters were mailed January 20, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022100009.
Affected Component: ELECTRICAL SYSTEM:SOFTWARE
Defect Summary: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error in the communication module's SIM card software can cause a mobile network connection failure, disabling the emergency call (eCall) system.
Free Manufacturer Remedy: The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022. Owner notification letters will be mailed in phases, on July 8, 2022, May 17, 2024, July 29, 2024, and September 27, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's numbers are for this recall is 2022060005 and 2023110006.
View all 2021 Mercedes-Benz CLS recalls & campaign history (8 campaigns) →