2021 Mercedes-Benz S-Class Specifications Overview
The 2021 Mercedes-Benz S-Class is certified across 12 configurations with 3L Gas-Electric Hybrid Engine, 4L 8-Cylinder Engine, 4L Gas-Electric Hybrid Engine powertrain options. Available drivetrain layouts include Rear-Wheel Drive, 4-Wheel Drive paired with Automatic 9-spd. EPA classified under the Compact Cars / Large Cars / Standard Sport Utility Vehicle 4WD / Subcompact Cars size category. Platform architecture belongs to the 7th Generation (W223) vehicle family.
Certified Powertrain & Transmission Configurations (12)
Official laboratory certification specifications for each factory engine, transmission, and drivetrain permutation
| Configuration / Model | Engine & Displacement | Cylinders | Induction / Tech | Transmission | Drivetrain | Fuel System |
|---|---|---|---|---|---|---|
| CLS450 Compact Cars | 3L Gas-Electric Hybrid Engine | 6 | Hybrid Electric Assist | Automatic 9-spd | Rear-Wheel Drive | Premium |
| CLS450 4matic Compact Cars | 3L Gas-Electric Hybrid Engine | 6 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| S500 4matic Large Cars | 3L Gas-Electric Hybrid Engine | 6 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| GLS450 4matic Standard Sport Utility Vehicle 4WD | 3L Gas-Electric Hybrid Engine | 6 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| S560 Convertible Subcompact Cars | 4L 8-Cylinder Engine | 8 | Naturally Aspirated | Automatic 9-spd | Rear-Wheel Drive | Premium |
| S560 4matic Coupe Compact Cars | 4L 8-Cylinder Engine | 8 | Naturally Aspirated | Automatic 9-spd | 4-Wheel Drive | Premium |
| S580 4matic Large Cars | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| AMG S63 4matic Plus Coupe Compact Cars | 4L 8-Cylinder Engine | 8 | Naturally Aspirated | Automatic 9-spd | 4-Wheel Drive | Premium |
| S580 4matic Maybach Large Cars | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| GLS580 4matic Standard Sport Utility Vehicle 4WD | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| AMG S63 4matic Plus Convertible Subcompact Cars | 4L 8-Cylinder Engine | 8 | Naturally Aspirated | Automatic 9-spd | 4-Wheel Drive | Premium |
| GLS600 4matic Maybach Standard Sport Utility Vehicle 4WD | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
Regulatory Classification & Safety Architecture
Federal classification standards and standard active driver assistance system capabilities
EPA Regulatory Size Class
- Compact Cars
- Large Cars
- Standard Sport Utility Vehicle 4WD
- Subcompact Cars
NHTSA NCAP Body Formats
- 2021 Mercedes-Benz S-Class 2 DR 4WD
- 2021 Mercedes-Benz S-Class 4 DR 4WD
- 2021 Mercedes-Benz S-Class Cabriolet C 4WD
- 2021 Mercedes-Benz S-Class 2 DR RWD
- 2021 Mercedes-Benz S-Class Cabriolet C RWD
Active Safety Technology
Evaluated under federal safety compliance standards.
Powertrain, transmission, drivetrain, and regulatory classification specifications on this page are derived directly from the United States Environmental Protection Agency (EPA) and National Highway Traffic Safety Administration (NHTSA) official laboratory certification registries.
Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.