2022 Mercedes-Benz S-Class Specifications Overview
The 2022 Mercedes-Benz S-Class is certified across 9 configurations with Electric Drive Motor(s), 3L Gas-Electric Hybrid Engine, 4L Gas-Electric Hybrid Engine, 6L 12-Cylinder Engine powertrain options. Available drivetrain layouts include All-Wheel Drive, 4-Wheel Drive paired with Automatic (A1) or Automatic 9-spd. EPA classified under the Large Cars / Compact Cars / Standard Sport Utility Vehicle 4WD size category. Platform architecture belongs to the 7th Generation (W223) vehicle family.
Certified Powertrain & Transmission Configurations (9)
Official laboratory certification specifications for each factory engine, transmission, and drivetrain permutation
| Configuration / Model | Engine & Displacement | Cylinders | Induction / Tech | Transmission | Drivetrain | Fuel System |
|---|---|---|---|---|---|---|
| EQS 580 4matic Large Cars | Electric Drive Motor(s) | 0 | Permanent Magnet Motor | Automatic (A1) | All-Wheel Drive | Electricity |
| CLS450 4matic Compact Cars | 3L Gas-Electric Hybrid Engine | 6 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| S500 4matic Large Cars | 3L Gas-Electric Hybrid Engine | 6 | Hybrid Electric Assist | Automatic 9-spd | All-Wheel Drive | Premium |
| GLS450 4matic Standard Sport Utility Vehicle 4WD | 3L Gas-Electric Hybrid Engine | 6 | Hybrid Electric Assist | Automatic 9-spd | 4-Wheel Drive | Premium |
| S580 4matic Large Cars | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | All-Wheel Drive | Premium |
| S580 4matic Maybach Large Cars | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | All-Wheel Drive | Premium |
| GLS580 4matic Standard Sport Utility Vehicle 4WD | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | All-Wheel Drive | Premium |
| GLS600 4matic Maybach Standard Sport Utility Vehicle 4WD | 4L Gas-Electric Hybrid Engine | 8 | Hybrid Electric Assist | Automatic 9-spd | All-Wheel Drive | Premium |
| Maybach S680 4matic Large Cars | 6L 12-Cylinder Engine | 12 | Naturally Aspirated | Automatic 9-spd | All-Wheel Drive | Premium |
Regulatory Classification & Safety Architecture
Federal classification standards and standard active driver assistance system capabilities
EPA Regulatory Size Class
- Large Cars
- Compact Cars
- Standard Sport Utility Vehicle 4WD
NHTSA NCAP Body Formats
- 2022 Mercedes-Benz S-Class 4 DR 4WD
- 2022 Mercedes-Benz S-Class 4 DR RWD
Active Safety Technology
Evaluated under federal safety compliance standards.
Powertrain, transmission, drivetrain, and regulatory classification specifications on this page are derived directly from the United States Environmental Protection Agency (EPA) and National Highway Traffic Safety Administration (NHTSA) official laboratory certification registries.
Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.