The 2016 Mercedes-Benz E-Class delivers an EPA-certified 18–25 MPG combined across 24 configurations. Estimated annual fuel costs range from $3,200 to $4,200.
Factual efficiency differences across gasoline, hybrid, plug-in hybrid, and electric variants
Annual Fuel Cost: $3,200–$4,200.
Gasoline Combined: 21 MPG • Annual Cost: $3,600.
Laboratory certification test values across engine, transmission, and drivetrain permutations
| Configuration / Model | Powertrain | Drivetrain | Transmission | City | Highway | Combined | EV Range | Annual Fuel Cost | CO2 (g/mi) |
|---|---|---|---|---|---|---|---|---|---|
| GLE350 d 4matic Diesel | 3L Turbo-Diesel | 4-Wheel Drive | Automatic 9-spd | 23 MPG | 29 MPG | 25 MPG | — | $3,200 | — |
| GLE300 d 4matic Diesel | 2.1L Turbo-Diesel | 4-Wheel Drive | Automatic 7-spd | 22 MPG | 29 MPG | 24 MPG | — | $3,300 | — |
| E400 Coupe Premium | 3L 6-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 20 MPG | 29 MPG | 23 MPG | — | $3,300 | — |
| E400 4matic Coupe Premium | 3L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 20 MPG | 28 MPG | 23 MPG | — | $3,300 | — |
| E400 Convertible Premium | 3L 6-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 20 MPG | 29 MPG | 23 MPG | — | $3,300 | — |
| E400 Premium | 3L 6-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 20 MPG | 29 MPG | 23 MPG | — | $3,300 | — |
| E350 Premium or E85 | 3.5L 6-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 20 MPG | 29 MPG | 23 MPG | — | $3,300 | — |
| E350 4matic Premium or E85 | 3.5L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 20 MPG | 27 MPG | 23 MPG | — | $3,300 | — |
| E350 Premium | 3.5L 6-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 20 MPG | 28 MPG | 23 MPG | — | $3,300 | — |
| E350 4matic Premium | 3.5L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 20 MPG | 27 MPG | 23 MPG | — | $3,300 | — |
| E400 4matic Premium | 3L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 20 MPG | 27 MPG | 22 MPG | — | $3,450 | — |
| E350 4matic (wagon) Premium | 3.5L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 20 MPG | 26 MPG | 22 MPG | — | $3,450 | — |
| GLE550e 4matic Premium and Electricity | 3L Plug-in Hybrid | 4-Wheel Drive | Automatic 7-spd | 39 MPGe (20 MPG) | 50 MPGe (23 MPG) | 43 MPGe (21 MPG) | 12 mi | $3,600 | — |
| E550 Coupe Premium | 4.7L 8-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 18 MPG | 26 MPG | 21 MPG | — | $3,600 | — |
| E550 4matic Premium | 4.7L 8-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 18 MPG | 24 MPG | 21 MPG | — | $3,600 | — |
| E550 Convertible Premium | 4.7L 8-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 17 MPG | 25 MPG | 20 MPG | — | $3,800 | — |
| GLE350 Premium | 3.5L 6-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 18 MPG | 23 MPG | 20 MPG | — | $3,800 | — |
| GLE450 AMG Coupe Premium | 3L 6-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 17 MPG | 23 MPG | 20 MPG | — | $3,800 | — |
| GLE400 4matic Premium | 3L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 18 MPG | 22 MPG | 20 MPG | — | $3,800 | — |
| AMG E63 4matic Premium | 5.5L 8-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 16 MPG | 23 MPG | 19 MPG | — | $4,000 | — |
| GLE350 4matic Premium | 3.5L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 18 MPG | 22 MPG | 19 MPG | — | $4,000 | — |
| GLE350 4matic Premium or E85 | 3.5L 6-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 18 MPG | 22 MPG | 19 MPG | — | $4,000 | — |
| AMG E63 S 4matic Premium | 5.5L 8-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 15 MPG | 22 MPG | 18 MPG | — | $4,200 | — |
| AMG E63 S 4matic (wagon) Premium | 5.5L 8-Cyl Gas | 4-Wheel Drive | Automatic 7-spd | 16 MPG | 21 MPG | 18 MPG | — | $4,200 | — |
Standardized annual energy consumption and operating cost metrics based on 15,000 annual miles
Based on $3.50 per gallon regular gasoline
Estimated annual energy units needed for 15,000 miles
Compared to the average new vehicle over 5 years
Cross-reference safety ratings, owner defect complaints, and recall campaigns
Vehicle summary, specifications, and primary KPI metrics.
NHTSA 5-Star NCAP crash tests, rollover risk, and active driver assistance.
NHTSA consumer defect complaint filings by affected component.
Official safety recall notices, defects, and free repair instructions.
Direct, deterministic answers synthesized from verified United States government databases for the 2016 Mercedes-Benz E-Class
The 2016 Mercedes-Benz E-Class achieves an EPA-certified rating of 18 to 25 MPG combined across 24 certified configuration(s).
City ratings range from 15 to 25 MPG, and highway ratings range from 18 to 29 MPG.
The 2016 Mercedes-Benz E-Class plug-in hybrid (PHEV) delivers up to 0 miles of all-electric driving range before transitioning to hybrid gasoline operation.
In electric mode, efficiency is rated at 21 MPGe, switching to 0 MPG combined on gasoline.
Using AutoUtility's standardized operating cost model, estimated annual fueling and energy costs range between $3,200 and $4,200 for the 2016 Mercedes-Benz E-Class.
Calculated under AutoUtility's standardized methodology (15,000 miles per year, 55% city / 45% highway driving, $3.50/gallon regular gasoline, $0.16/kWh electricity) using official EPA dynamometer consumption ratings.
Fuel economy ratings, electric range figures, and energy cost estimates on this page are retrieved directly from the United States Environmental Protection Agency (EPA) and U.S. Department of Energy (FuelEconomy.gov) certified vehicle database under 40 CFR Part 600.
Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.