2016 Mercedes-Benz E-Class EPA Fuel Economy Summary

The 2016 Mercedes-Benz E-Class delivers an EPA-certified 18–25 MPG combined (15–23 city / 21–29 highway depending on engine and drivetrain) across 24 configurations. Plug-in hybrid (PHEV) models offer up to 12 miles of all-electric range at 43 MPGe. Estimated annual fuel costs range from $3,200 to $4,200.

Combined MPG
18–25 MPG
55% city / 45% highway weighted
City MPG
15–23 MPG
Stop-and-go urban cycle
Highway MPG
21–29 MPG
Sustained open-highway test
Annual Fuel Cost
$3,200–4,200
EPA estimate @ 15,000 miles/yr

2016 Mercedes-Benz E-Class Powertrain & Efficiency Comparison

Factual efficiency differences across gasoline, hybrid, plug-in hybrid, and electric variants

Internal Combustion

Standard Gasoline Trims

18–25 MPG Combined

Annual Fuel Cost: $3,200–$4,200 (23 configurations)

Plug-In Hybrid

Plug-In Hybrid (PHEV)

12 mi EV Range • 43 MPGe

Gasoline Combined: 21 MPG • Annual Energy Cost: $3,600

Official EPA Fuel Economy Ratings by Configuration (24 Variants)

Laboratory certification test values across engine, transmission, and drivetrain permutations

Configuration / Model Powertrain Drivetrain Transmission City Highway Combined EV Range Annual Fuel Cost CO2 (g/mi)
GLE350 d 4matic Diesel 3L Turbo-Diesel 4-Wheel Drive Automatic 9-spd 23 MPG 29 MPG 25 MPG — $3,200 —
GLE300 d 4matic Diesel 2.1L Turbo-Diesel 4-Wheel Drive Automatic 7-spd 22 MPG 29 MPG 24 MPG — $3,300 —
E400 Coupe Premium 3L 6-Cyl Gas Rear-Wheel Drive Automatic 7-spd 20 MPG 29 MPG 23 MPG — $3,300 —
E400 4matic Coupe Premium 3L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 20 MPG 28 MPG 23 MPG — $3,300 —
E400 Convertible Premium 3L 6-Cyl Gas Rear-Wheel Drive Automatic 7-spd 20 MPG 29 MPG 23 MPG — $3,300 —
E400 Premium 3L 6-Cyl Gas Rear-Wheel Drive Automatic 7-spd 20 MPG 29 MPG 23 MPG — $3,300 —
E350 Premium or E85 3.5L 6-Cyl Gas Rear-Wheel Drive Automatic 7-spd 20 MPG 29 MPG 23 MPG — $3,300 —
E350 4matic Premium or E85 3.5L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 20 MPG 27 MPG 23 MPG — $3,300 —
E350 Premium 3.5L 6-Cyl Gas Rear-Wheel Drive Automatic 7-spd 20 MPG 28 MPG 23 MPG — $3,300 —
E350 4matic Premium 3.5L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 20 MPG 27 MPG 23 MPG — $3,300 —
E400 4matic Premium 3L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 20 MPG 27 MPG 22 MPG — $3,450 —
E350 4matic (wagon) Premium 3.5L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 20 MPG 26 MPG 22 MPG — $3,450 —
GLE550e 4matic Premium and Electricity 3L Plug-in Hybrid 4-Wheel Drive Automatic 7-spd 39 MPGe (20 MPG) 50 MPGe (23 MPG) 43 MPGe (21 MPG) 12 mi $3,600 —
E550 Coupe Premium 4.7L 8-Cyl Gas Rear-Wheel Drive Automatic 7-spd 18 MPG 26 MPG 21 MPG — $3,600 —
E550 4matic Premium 4.7L 8-Cyl Gas 4-Wheel Drive Automatic 7-spd 18 MPG 24 MPG 21 MPG — $3,600 —
E550 Convertible Premium 4.7L 8-Cyl Gas Rear-Wheel Drive Automatic 7-spd 17 MPG 25 MPG 20 MPG — $3,800 —
GLE350 Premium 3.5L 6-Cyl Gas Rear-Wheel Drive Automatic 7-spd 18 MPG 23 MPG 20 MPG — $3,800 —
GLE450 AMG Coupe Premium 3L 6-Cyl Gas 4-Wheel Drive Automatic 9-spd 17 MPG 23 MPG 20 MPG — $3,800 —
GLE400 4matic Premium 3L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 18 MPG 22 MPG 20 MPG — $3,800 —
AMG E63 4matic Premium 5.5L 8-Cyl Gas 4-Wheel Drive Automatic 7-spd 16 MPG 23 MPG 19 MPG — $4,000 —
GLE350 4matic Premium 3.5L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 18 MPG 22 MPG 19 MPG — $4,000 —
GLE350 4matic Premium or E85 3.5L 6-Cyl Gas 4-Wheel Drive Automatic 7-spd 18 MPG 22 MPG 19 MPG — $4,000 —
AMG E63 S 4matic Premium 5.5L 8-Cyl Gas 4-Wheel Drive Automatic 7-spd 15 MPG 22 MPG 18 MPG — $4,200 —
AMG E63 S 4matic (wagon) Premium 5.5L 8-Cyl Gas 4-Wheel Drive Automatic 7-spd 16 MPG 21 MPG 18 MPG — $4,200 —
EPA Test Methodology: Fuel economy estimates are determined by vehicle manufacturers in accordance with EPA regulations (40 CFR Part 600) and verified by EPA laboratories. Estimates assume 15,000 miles per year of driving (55% city, 45% highway) at prevailing fuel and electricity prices.

Deterministic Fuel Cost & Consumption Benchmarks

Standardized annual energy consumption and operating cost metrics based on 15,000 annual miles

Fuel Cost per 25 Miles

$3.50–$4.86

Based on $3.50 per gallon regular gasoline

Annual Fuel Consumption

600–833 Gallons

Estimated annual energy units needed for 15,000 miles

5-Year Fuel Cost vs Avg Vehicle

Official EPA Benchmark

Compared to the average new vehicle over 5 years

Related Official Reports for 2016 Mercedes-Benz E-Class

Cross-reference safety ratings, owner defect complaints, and recall campaigns

Official US Government Data Provenance

Fuel economy ratings, electric range figures, and energy cost estimates on this page are retrieved directly from the United States Environmental Protection Agency (EPA) and U.S. Department of Energy (FuelEconomy.gov) certified vehicle database.

Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.