2021 Mercedes-Benz E-Class Specifications Overview

The 2021 Mercedes-Benz E-Class is certified across 16 configurations with 3L Gas-Electric Hybrid Engine, 2L 4-Cylinder Engine, 4L 8-Cylinder Engine powertrain options. Available drivetrain layouts include 4-Wheel Drive, Rear-Wheel Drive paired with Automatic 9-spd. EPA classified under the Midsize Cars / Subcompact Cars / Midsize Station Wagons / Standard Sport Utility Vehicle 4WD / Small Sport Utility Vehicle 4WD size category. Platform architecture belongs to the 5th Generation (W213) vehicle family.

Engine / Motors
3 Options
3L Gas-Electric Hybrid Engine, 2L 4-Cylinder Engine...
Drivetrain Options
2 Drivetrains
4-Wheel Drive, Rear-Wheel Drive
Transmissions
Automatic 9-spd
Automatic 9-spd
Vehicle Classification
Midsize Cars
Official EPA regulatory class

Certified Powertrain & Transmission Configurations (16)

Official laboratory certification specifications for each factory engine, transmission, and drivetrain permutation

Configuration / Model Engine & Displacement Cylinders Induction / Tech Transmission Drivetrain Fuel System
E450 4matic Midsize Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
E450 Coupe Subcompact Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd Rear-Wheel Drive Premium
E350 Midsize Cars 2L 4-Cylinder Engine 4 Naturally Aspirated Automatic 9-spd Rear-Wheel Drive Premium
E350 4matic Midsize Cars 2L 4-Cylinder Engine 4 Naturally Aspirated Automatic 9-spd 4-Wheel Drive Premium
E450 4matic Coupe Subcompact Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
E450 Convertible Subcompact Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd Rear-Wheel Drive Premium
E450 4matic Convertible Subcompact Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
AMG E53 4matic Plus Midsize Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
E450 4matic All-Terrain (wagon) Midsize Station Wagons 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
AMG E53 4matic Plus Coupe Subcompact Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
GLE450 4matic Standard Sport Utility Vehicle 4WD 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
AMG E53 4matic Plus Convertible Subcompact Cars 3L Gas-Electric Hybrid Engine 6 Hybrid Electric Assist Automatic 9-spd 4-Wheel Drive Premium
GLE350 Small Sport Utility Vehicle 4WD 2L 4-Cylinder Engine 4 Naturally Aspirated Automatic 9-spd Rear-Wheel Drive Premium
GLE350 4matic Small Sport Utility Vehicle 4WD 2L 4-Cylinder Engine 4 Naturally Aspirated Automatic 9-spd 4-Wheel Drive Premium
AMG E63 S 4matic Plus Midsize Cars 4L 8-Cylinder Engine 8 Naturally Aspirated Automatic 9-spd 4-Wheel Drive Premium
AMG E63 S 4matic Plus (SW) Midsize Station Wagons 4L 8-Cylinder Engine 8 Naturally Aspirated Automatic 9-spd 4-Wheel Drive Premium
EPA Certification Standards: Powertrain and transmission specifications represent official laboratory configuration records filed under 40 CFR Part 600. For detailed fuel economy ratings, electric range, and annual fuel costs, explore the 2021 Mercedes-Benz E-Class MPG & Range Report.

Regulatory Classification & Safety Architecture

Federal classification standards and standard active driver assistance system capabilities

EPA Regulatory Size Class

  • Midsize Cars
  • Subcompact Cars
  • Midsize Station Wagons
  • Standard Sport Utility Vehicle 4WD
  • Small Sport Utility Vehicle 4WD

NHTSA NCAP Body Formats

  • 2021 Mercedes-Benz E-Class 2DR 4WD
  • 2021 Mercedes-Benz E-Class SW 4WD
  • 2021 Mercedes-Benz E-Class 4 DR 4WD
  • 2021 Mercedes-Benz E-Class Cabriolet C 4WD
  • 2021 Mercedes-Benz E-Class 2DR RWD
  • 2021 Mercedes-Benz E-Class SW RWD
  • 2021 Mercedes-Benz E-Class 4 DR RWD
  • 2021 Mercedes-Benz E-Class Cabriolet C RWD

Active Safety Technology

Evaluated under federal safety compliance standards.

Related Official Reports for 2021 Mercedes-Benz E-Class

Cross-reference fuel economy, safety ratings, owner defect complaints, and recall notices

Official US Government Data Provenance

Powertrain, transmission, drivetrain, and regulatory classification specifications on this page are derived directly from the United States Environmental Protection Agency (EPA) and National Highway Traffic Safety Administration (NHTSA) official laboratory certification registries.

Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.