2018 Mercedes-Benz S-Class EPA Fuel Economy Summary

The 2018 Mercedes-Benz S-Class delivers an EPA-certified 16–22 MPG combined (13–19 city / 19–28 highway depending on engine and drivetrain) across 18 configurations. Estimated annual fuel costs range from $3,450 to $4,750.

Combined MPG
16–22 MPG
55% city / 45% highway weighted
City MPG
13–19 MPG
Stop-and-go urban cycle
Highway MPG
19–28 MPG
Sustained open-highway test
Annual Fuel Cost
$3,450–4,750
EPA estimate @ 15,000 miles/yr

Official EPA Fuel Economy Ratings by Configuration (18 Variants)

Laboratory certification test values across engine, transmission, and drivetrain permutations

Configuration / Model Powertrain Drivetrain Transmission City Highway Combined Annual Fuel Cost CO2 (g/mi)
S450 Premium 3L 6-Cyl Gas Rear-Wheel Drive Automatic 9-spd 19 MPG 28 MPG 22 MPG $3,450 —
S450 4matic Premium 3L 6-Cyl Gas 4-Wheel Drive Automatic 9-spd 18 MPG 28 MPG 22 MPG $3,450 —
S560 4matic Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 17 MPG 27 MPG 21 MPG $3,600 —
CLS550 Premium 4.7L 8-Cyl Gas Rear-Wheel Drive Automatic 9-spd 18 MPG 26 MPG 21 MPG $3,600 —
S560 4matic Coupe Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 17 MPG 27 MPG 21 MPG $3,600 —
S560 Premium 4L 8-Cyl Gas Front-Wheel Drive Automatic 9-spd 17 MPG 27 MPG 21 MPG $3,600 —
AMG S63 4matic Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 17 MPG 26 MPG 20 MPG $3,800 —
CLS550 4matic Premium 4.7L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 17 MPG 25 MPG 20 MPG $3,800 —
S560 Convertible Premium 4L 8-Cyl Gas Front-Wheel Drive Automatic 9-spd 17 MPG 26 MPG 20 MPG $3,800 —
AMG S63 4matic Coupe Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 17 MPG 27 MPG 20 MPG $3,800 —
GLS450 4matic Premium 3L 6-Cyl Gas 4-Wheel Drive Automatic 9-spd 17 MPG 22 MPG 19 MPG $4,000 —
Maybach S560 4matic Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 16 MPG 25 MPG 19 MPG $4,000 —
AMG S63 4matic Convertible Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 15 MPG 24 MPG 18 MPG $4,200 —
GLS550 4matic Premium 4.7L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 14 MPG 19 MPG 16 MPG $4,750 —
Maybach S650 Premium 6L 12-Cyl Gas Rear-Wheel Drive Automatic 7-spd 13 MPG 21 MPG 16 MPG $4,750 —
AMG S65 Premium 6L 12-Cyl Gas Rear-Wheel Drive Automatic 7-spd 13 MPG 22 MPG 16 MPG $4,750 —
AMG S65 Convertible Premium 6L 12-Cyl Gas Rear-Wheel Drive Automatic 7-spd 14 MPG 21 MPG 16 MPG $4,750 —
AMG S65 Coupe Premium 6L 12-Cyl Gas Rear-Wheel Drive Automatic 7-spd 13 MPG 21 MPG 16 MPG $4,750 —
EPA Test Methodology: Fuel economy estimates are determined by vehicle manufacturers in accordance with EPA regulations (40 CFR Part 600) and verified by EPA laboratories. Estimates assume 15,000 miles per year of driving (55% city, 45% highway) at prevailing fuel and electricity prices.

Deterministic Fuel Cost & Consumption Benchmarks

Standardized annual energy consumption and operating cost metrics based on 15,000 annual miles

Fuel Cost per 25 Miles

$3.98–$5.47

Based on $3.50 per gallon regular gasoline

Annual Fuel Consumption

682–938 Gallons

Estimated annual energy units needed for 15,000 miles

5-Year Fuel Cost vs Avg Vehicle

Official EPA Benchmark

Compared to the average new vehicle over 5 years

Related Official Reports for 2018 Mercedes-Benz S-Class

Cross-reference safety ratings, owner defect complaints, and recall campaigns

Official US Government Data Provenance

Fuel economy ratings, electric range figures, and energy cost estimates on this page are retrieved directly from the United States Environmental Protection Agency (EPA) and U.S. Department of Energy (FuelEconomy.gov) certified vehicle database.

Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.