2019 Mercedes-Benz S-Class EPA Fuel Economy Summary
The 2019 Mercedes-Benz S-Class delivers an EPA-certified 16–26 MPG combined (13–24 city / 19–31 highway depending on engine and drivetrain) across 19 configurations. Hybrid variants achieve up to 26 MPG combined, compared to 22 MPG for standard gasoline trims. Plug-in hybrid (PHEV) models offer up to 19 miles of all-electric range at 64 MPGe. Estimated annual fuel costs range from $2,900 to $4,750.
2019 Mercedes-Benz S-Class Powertrain & Efficiency Comparison
Factual efficiency differences across gasoline, hybrid, plug-in hybrid, and electric variants
Standard Gasoline Trims
Annual Fuel Cost: $3,450–$4,750 (16 configurations)
Hybrid (HEV) Trims
Annual Fuel Cost: $2,900–$2,900 (Saves ~$550/yr vs gas)
Plug-In Hybrid (PHEV)
Gasoline Combined: 23 MPG • Annual Energy Cost: $3,300
Official EPA Fuel Economy Ratings by Configuration (19 Variants)
Laboratory certification test values across engine, transmission, and drivetrain permutations
| Configuration / Model | Powertrain | Drivetrain | Transmission | City | Highway | Combined | EV Range | Annual Fuel Cost | CO2 (g/mi) |
|---|---|---|---|---|---|---|---|---|---|
| CLS450 Premium | 3L Hybrid | Rear-Wheel Drive | Automatic 9-spd | 24 MPG | 31 MPG | 26 MPG | — | $2,900 | — |
| CLS450 4matic Premium | 3L Hybrid | 4-Wheel Drive | Automatic 9-spd | 23 MPG | 30 MPG | 26 MPG | — | $2,900 | — |
| S560e Premium and Electricity | 3L Plug-in Hybrid | Rear-Wheel Drive | Automatic 9-spd | 58 MPGe (21 MPG) | 73 MPGe (26 MPG) | 64 MPGe (23 MPG) | 19 mi | $3,300 | — |
| S450 Premium | 3L 6-Cyl Gas | Rear-Wheel Drive | Automatic 9-spd | 19 MPG | 28 MPG | 22 MPG | — | $3,450 | — |
| S450 4matic Premium | 3L 6-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 18 MPG | 28 MPG | 22 MPG | — | $3,450 | — |
| S560 4matic Premium | 4L 8-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 17 MPG | 27 MPG | 21 MPG | — | $3,600 | — |
| S560 Premium | 4L 8-Cyl Gas | Front-Wheel Drive | Automatic 9-spd | 17 MPG | 27 MPG | 21 MPG | — | $3,600 | — |
| S560 Convertible Premium | 4L 8-Cyl Gas | Front-Wheel Drive | Automatic 9-spd | 17 MPG | 26 MPG | 20 MPG | — | $3,800 | — |
| AMG S63 4matic Coupe Premium | 4L 8-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 17 MPG | 27 MPG | 20 MPG | — | $3,800 | — |
| AMG S63 4matic Premium | 4L 8-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 17 MPG | 26 MPG | 20 MPG | — | $3,800 | — |
| S560 4matic Coupe Premium | 4L 8-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 17 MPG | 26 MPG | 20 MPG | — | $3,800 | — |
| Maybach S560 4matic Premium | 4L 8-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 16 MPG | 25 MPG | 19 MPG | — | $4,000 | — |
| GLS450 4matic Premium | 3L 6-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 16 MPG | 22 MPG | 18 MPG | — | $4,200 | — |
| AMG S63 4matic Convertible Premium | 4L 8-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 15 MPG | 24 MPG | 18 MPG | — | $4,200 | — |
| GLS550 4matic Premium | 4.7L 8-Cyl Gas | 4-Wheel Drive | Automatic 9-spd | 14 MPG | 19 MPG | 16 MPG | — | $4,750 | — |
| AMG S65 Convertible Premium | 6L 12-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 14 MPG | 21 MPG | 16 MPG | — | $4,750 | — |
| AMG S65 Coupe Premium | 6L 12-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 13 MPG | 21 MPG | 16 MPG | — | $4,750 | — |
| Maybach S650 Premium | 6L 12-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 13 MPG | 21 MPG | 16 MPG | — | $4,750 | — |
| AMG S65 Premium | 6L 12-Cyl Gas | Rear-Wheel Drive | Automatic 7-spd | 13 MPG | 22 MPG | 16 MPG | — | $4,750 | — |
Deterministic Fuel Cost & Consumption Benchmarks
Standardized annual energy consumption and operating cost metrics based on 15,000 annual miles
Fuel Cost per 25 Miles
Based on $3.50 per gallon regular gasoline
Annual Fuel Consumption
Estimated annual energy units needed for 15,000 miles
5-Year Fuel Cost vs Avg Vehicle
Compared to the average new vehicle over 5 years
Fuel economy ratings, electric range figures, and energy cost estimates on this page are retrieved directly from the United States Environmental Protection Agency (EPA) and U.S. Department of Energy (FuelEconomy.gov) certified vehicle database.
Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.