2021 Mercedes-Benz S-Class EPA Fuel Economy Summary

The 2021 Mercedes-Benz S-Class delivers an EPA-certified 16–26 MPG combined (14–23 city / 19–30 highway depending on engine and drivetrain) across 12 configurations. Hybrid variants achieve up to 26 MPG combined, compared to 20 MPG for standard gasoline trims. Estimated annual fuel costs range from $2,900 to $4,750.

Combined MPG
16–26 MPG
55% city / 45% highway weighted
City MPG
14–23 MPG
Stop-and-go urban cycle
Highway MPG
19–30 MPG
Sustained open-highway test
Annual Fuel Cost
$2,900–4,750
EPA estimate @ 15,000 miles/yr

2021 Mercedes-Benz S-Class Powertrain & Efficiency Comparison

Factual efficiency differences across gasoline, hybrid, plug-in hybrid, and electric variants

Internal Combustion

Standard Gasoline Trims

17–20 MPG Combined

Annual Fuel Cost: $3,800–$4,450 (4 configurations)

Gas-Electric Hybrid

Hybrid (HEV) Trims

16–26 MPG Combined

Annual Fuel Cost: $2,900–$4,750 (Saves ~$900/yr vs gas)

Official EPA Fuel Economy Ratings by Configuration (12 Variants)

Laboratory certification test values across engine, transmission, and drivetrain permutations

Configuration / Model Powertrain Drivetrain Transmission City Highway Combined Annual Fuel Cost CO2 (g/mi)
CLS450 Premium 3L Hybrid Rear-Wheel Drive Automatic 9-spd 23 MPG 30 MPG 26 MPG $2,900 —
CLS450 4matic Premium 3L Hybrid 4-Wheel Drive Automatic 9-spd 22 MPG 29 MPG 25 MPG $3,050 —
S500 4matic Premium 3L Hybrid 4-Wheel Drive Automatic 9-spd 20 MPG 29 MPG 24 MPG $3,150 —
GLS450 4matic Premium 3L Hybrid 4-Wheel Drive Automatic 9-spd 20 MPG 24 MPG 21 MPG $3,600 —
S560 Convertible Premium 4L 8-Cyl Gas Rear-Wheel Drive Automatic 9-spd 16 MPG 26 MPG 20 MPG $3,800 —
S560 4matic Coupe Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 16 MPG 26 MPG 20 MPG $3,800 —
S580 4matic Premium 4L Hybrid 4-Wheel Drive Automatic 9-spd 17 MPG 25 MPG 20 MPG $3,800 —
AMG S63 4matic Plus Coupe Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 16 MPG 26 MPG 19 MPG $4,000 —
S580 4matic Maybach Premium 4L Hybrid 4-Wheel Drive Automatic 9-spd 16 MPG 24 MPG 19 MPG $4,000 —
GLS580 4matic Premium 4L Hybrid 4-Wheel Drive Automatic 9-spd 16 MPG 21 MPG 18 MPG $4,200 —
AMG S63 4matic Plus Convertible Premium 4L 8-Cyl Gas 4-Wheel Drive Automatic 9-spd 14 MPG 24 MPG 17 MPG $4,450 —
GLS600 4matic Maybach Premium 4L Hybrid 4-Wheel Drive Automatic 9-spd 15 MPG 19 MPG 16 MPG $4,750 —
EPA Test Methodology: Fuel economy estimates are determined by vehicle manufacturers in accordance with EPA regulations (40 CFR Part 600) and verified by EPA laboratories. Estimates assume 15,000 miles per year of driving (55% city, 45% highway) at prevailing fuel and electricity prices.

Deterministic Fuel Cost & Consumption Benchmarks

Standardized annual energy consumption and operating cost metrics based on 15,000 annual miles

Fuel Cost per 25 Miles

$3.37–$5.47

Based on $3.50 per gallon regular gasoline

Annual Fuel Consumption

577–938 Gallons

Estimated annual energy units needed for 15,000 miles

5-Year Fuel Cost vs Avg Vehicle

Official EPA Benchmark

Compared to the average new vehicle over 5 years

Related Official Reports for 2021 Mercedes-Benz S-Class

Cross-reference safety ratings, owner defect complaints, and recall campaigns

Official US Government Data Provenance

Fuel economy ratings, electric range figures, and energy cost estimates on this page are retrieved directly from the United States Environmental Protection Agency (EPA) and U.S. Department of Energy (FuelEconomy.gov) certified vehicle database.

Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.