2022 Mercedes-Benz S-Class EPA Fuel Economy Summary
The 2022 Mercedes-Benz S-Class delivers an EPA-certified 15–25 MPG combined (12–22 city / 20–30 highway depending on engine and drivetrain) across 9 configurations. Hybrid variants achieve up to 25 MPG combined, compared to 15 MPG for standard gasoline trims. Estimated annual fuel costs range from $800 to $5,050.
2022 Mercedes-Benz S-Class Powertrain & Efficiency Comparison
Factual efficiency differences across gasoline, hybrid, plug-in hybrid, and electric variants
Standard Gasoline Trims
Annual Fuel Cost: $5,050–$5,050 (1 configuration)
Hybrid (HEV) Trims
Annual Fuel Cost: $3,050–$4,450 (Saves ~$2,000/yr vs gas)
Battery Electric (BEV)
Annual Energy Cost: $800–$5,050 (1 configuration)
Official EPA Fuel Economy Ratings by Configuration (9 Variants)
Laboratory certification test values across engine, transmission, and drivetrain permutations
| Configuration / Model | Powertrain | Drivetrain | Transmission | City | Highway | Combined | EV Range | Annual Fuel Cost | CO2 (g/mi) |
|---|---|---|---|---|---|---|---|---|---|
| EQS 580 4matic Electricity | Electric (BEV) | All-Wheel Drive | Automatic (A1) | 92 MPGe | 99 MPGe | 95 MPGe | 340 mi | $800 | — |
| CLS450 4matic Premium | 3L Hybrid | 4-Wheel Drive | Automatic 9-spd | 22 MPG | 30 MPG | 25 MPG | — | $3,050 | — |
| S500 4matic Premium | 3L Hybrid | All-Wheel Drive | Automatic 9-spd | 21 MPG | 30 MPG | 24 MPG | — | $3,150 | — |
| GLS450 4matic Premium | 3L Hybrid | 4-Wheel Drive | Automatic 9-spd | 18 MPG | 24 MPG | 20 MPG | — | $3,800 | — |
| S580 4matic Premium | 4L Hybrid | All-Wheel Drive | Automatic 9-spd | 16 MPG | 25 MPG | 19 MPG | — | $4,000 | — |
| S580 4matic Maybach Premium | 4L Hybrid | All-Wheel Drive | Automatic 9-spd | 15 MPG | 24 MPG | 18 MPG | — | $4,200 | — |
| GLS580 4matic Premium | 4L Hybrid | All-Wheel Drive | Automatic 9-spd | 16 MPG | 21 MPG | 18 MPG | — | $4,200 | — |
| GLS600 4matic Maybach Premium | 4L Hybrid | All-Wheel Drive | Automatic 9-spd | 14 MPG | 20 MPG | 17 MPG | — | $4,450 | — |
| Maybach S680 4matic Premium | 6L 12-Cyl Gas | All-Wheel Drive | Automatic 9-spd | 12 MPG | 21 MPG | 15 MPG | — | $5,050 | — |
Deterministic Fuel Cost & Consumption Benchmarks
Standardized annual energy consumption and operating cost metrics based on 15,000 annual miles
Fuel Cost per 25 Miles
Based on $3.50 per gallon regular gasoline
Annual Fuel Consumption
Estimated annual energy units needed for 15,000 miles
5-Year Fuel Cost vs Avg Vehicle
Compared to the average new vehicle over 5 years
Fuel economy ratings, electric range figures, and energy cost estimates on this page are retrieved directly from the United States Environmental Protection Agency (EPA) and U.S. Department of Energy (FuelEconomy.gov) certified vehicle database.
Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.