2024 Mercedes-Benz S-Class EPA Fuel Economy Summary

The 2024 Mercedes-Benz S-Class delivers an EPA-certified 15–24 MPG combined (12–21 city / 19–31 highway depending on engine and drivetrain) across 11 configurations. Hybrid variants achieve up to 24 MPG combined, compared to 15 MPG for standard gasoline trims. Estimated annual fuel costs range from $800 to $5,050.

Combined MPG
15–24 MPG
55% city / 45% highway weighted
City MPG
12–21 MPG
Stop-and-go urban cycle
Highway MPG
19–31 MPG
Sustained open-highway test
Annual Fuel Cost
$800–5,050
EPA estimate @ 15,000 miles/yr

2024 Mercedes-Benz S-Class Powertrain & Efficiency Comparison

Factual efficiency differences across gasoline, hybrid, plug-in hybrid, and electric variants

Internal Combustion

Standard Gasoline Trims

15–15 MPG Combined

Annual Fuel Cost: $5,050–$5,050 (1 configuration)

Gas-Electric Hybrid

Hybrid (HEV) Trims

16–24 MPG Combined

Annual Fuel Cost: $3,150–$4,750 (Saves ~$1,900/yr vs gas)

All-Electric

Battery Electric (BEV)

280–345 mi Range • 96 MPGe

Annual Energy Cost: $800–$5,050 (4 configurations)

Official EPA Fuel Economy Ratings by Configuration (11 Variants)

Laboratory certification test values across engine, transmission, and drivetrain permutations

Configuration / Model Powertrain Drivetrain Transmission City Highway Combined EV Range Annual Fuel Cost CO2 (g/mi)
EQS 580 4matic Electricity Electric (BEV) All-Wheel Drive Automatic (A1) 95 MPGe 98 MPGe 96 MPGe 345 mi $800
EQS 580 4matic (SUV) Electricity Electric (BEV) All-Wheel Drive Automatic (A1) 85 MPGe 81 MPGe 83 MPGe 330 mi $900
EQS 680 4matic Maybach (SUV) Electricity Electric (BEV) All-Wheel Drive Automatic (A1) 81 MPGe 81 MPGe 81 MPGe 321 mi $950
EQS 680 4matic Maybach (SUV) Electricity Electric (BEV) All-Wheel Drive Automatic (A1) 75 MPGe 77 MPGe 76 MPGe 280 mi $1,000
S500 4matic Premium 3L Hybrid All-Wheel Drive Automatic 9-spd 21 MPG 31 MPG 24 MPG $3,150
GLS450 4matic Premium 3L Hybrid All-Wheel Drive Automatic 9-spd 19 MPG 24 MPG 21 MPG $3,600
S580 4matic Maybach Premium 4L Hybrid All-Wheel Drive Automatic 9-spd 18 MPG 26 MPG 21 MPG $3,600
S580 4matic Premium 4L Hybrid All-Wheel Drive Automatic 9-spd 18 MPG 27 MPG 21 MPG $3,600
GLS580 4matic Premium 4L Hybrid All-Wheel Drive Automatic 9-spd 14 MPG 20 MPG 16 MPG $4,750
GLS600 4matic Maybach Premium 4L Hybrid All-Wheel Drive Automatic 9-spd 14 MPG 19 MPG 16 MPG $4,750
Maybach S680 4matic Premium 6L 12-Cyl Gas All-Wheel Drive Automatic 9-spd 12 MPG 20 MPG 15 MPG $5,050
EPA Test Methodology: Fuel economy estimates are determined by vehicle manufacturers in accordance with EPA regulations (40 CFR Part 600) and verified by EPA laboratories. Estimates assume 15,000 miles per year of driving (55% city, 45% highway) at prevailing fuel and electricity prices.

Deterministic Fuel Cost & Consumption Benchmarks

Standardized annual energy consumption and operating cost metrics based on 15,000 annual miles

Fuel Cost per 25 Miles

$3.65–$5.83

Based on $3.50 per gallon regular gasoline

Annual Fuel Consumption

625–1000 Gallons

Estimated annual energy units needed for 15,000 miles

5-Year Fuel Cost vs Avg Vehicle

Official EPA Benchmark

Compared to the average new vehicle over 5 years

Official US Government Data Provenance

Fuel economy ratings, electric range figures, and energy cost estimates on this page are retrieved directly from the United States Environmental Protection Agency (EPA) and U.S. Department of Energy (FuelEconomy.gov) certified vehicle database.

Local Production Store Compiled: August 2026 • Deterministic Audited Dataset • Zero Dynamic External API Runtime Latency.